|
|
prostaglandin_H2 + acceptor + H2O <=> prostaglandin_G2 + reduced_acceptor
|
1.14.99.1
prostaglandin-endoperoxide synthase
|
–
|
| |
BRENDA:
BS415735
KEGG:
R00073
MetaCyc:
RXN-16677
|
|
|
|
phosphatidylcholine + H2O <=> lysophosphatidylcholine + arachidonic_acid
|
3.1.1.4
phospholipase A2
|
–
|
| |
KEGG:
R01317
|
|
|
|
prostaglandin_H2 <=> prostaglandin_E2
|
5.3.99.3
prostaglandin-E synthase
|
–
|
| |
BRENDA:
BR48832
KEGG:
R02265
MetaCyc:
PROSTAGLANDIN-E-SYNTHASE-RXN
SABIO-RK:
2232
|
|
|
|
H2O + hepoxilin_A3 <=> Trioxilin_A3
|
3.3.2.7
hepoxilin-epoxide hydrolase
|
–
|
| |
BRENDA:
BR48210
KEGG:
R04609;
R07036
MetaCyc:
HEPOXILIN-EPOXIDE-HYDROLASE-RXN
|
|
|
|
leukotriene_D4 + H2O <=> glycine + leukotriene_E4
|
2.3.2
3.4.13.19
membrane dipeptidase
|
–
–
|
| |
KEGG:
R05055
MetaCyc:
RXN66-337
|
|
|
|
Prostaglandin_A2 <=> Prostaglandin_C2
|
not assigned
|
–
|
| |
KEGG:
R05056
|
|
|
|
thioredoxin + prostaglandin_H2 <=> thioredoxin_disulfide + prostaglandin_F2alpha
|
1.11.1.20
prostamide/prostaglandin F2alpha synthase
|
–
|
| |
BRENDA:
BR49412
KEGG:
R09506
MetaCyc:
RXN-12122
SABIO-RK:
15153
|
|
|
|
leukotriene_E4 + O2 + NADPH + H+ <=> 20-hydroxy-leukotriene_E4 + H2O + NADP+
|
1.14.13.34
leukotriene-E4 20-monooxygenase
|
–
|
| |
BRENDA:
BR40421
KEGG:
R04256
MetaCyc:
LEUKOTRIENE-E4-20-MONOOXYGENASE-RXN
|
|
|
|
arachidonic_acid + O2 + NADPH + H+ <=> 16(R)-HETE + NADP+ + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
| |
KEGG:
R07054
|
|
|
|
5,6-Epoxytetraene + H2O <=> lipoxin_A4
|
3.3.2
|
–
|
| |
KEGG:
R07031
|
|
|
|
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic_acid + H2O <=> (5Z,11Z,14Z)-8,9-dihydroxyeicosa-5,11,14-trienoic_acid
|
3.3.2.10
soluble epoxide hydrolase
3.3.2.9
microsomal epoxide hydrolase
|
–
–
|
| |
BRENDA:
BS403048
KEGG:
R07110
|
|
|
|
arachidonic_acid + reduced_flavodoxin + O2 <=> 19(S)-HETE + flavin + H2O
|
1.14.13
1.14.14
1.14.14.1
unspecific monooxygenase
1.14.14.80
long-chain fatty acid omega-monooxygenase
|
–
–
–
–
|
| |
KEGG:
R07046
|
|
|
|
arachidonic_acid + O2 <=> 15-hydroperoxyeicosatetraenoic_acid
|
1.13.11.12
linoleate 13S-lipoxygenase
1.13.11.33
arachidonate 15-lipoxygenase
|
–
–
|
| |
BRENDA:
BR47601
KEGG:
R01593
MetaCyc:
ARACHIDONATE-15-LIPOXYGENASE-RXN
SABIO-RK:
1742
|
|
|
|
arachidonic_acid + O2 + NADPH + H+ <=> (5Z,11Z,14Z)-8,9-epoxyeicosatrienoic_acid + NADP+ + H2O
|
1.14.13
1.14.14
1.14.14.1
unspecific monooxygenase
|
–
–
–
|
| |
KEGG:
R07051
|
|
|
|
NADP+ + (15S)-hydroxyeicosatetraenoic_acid <=> NADPH + 15-Oxo-5,8,11-cis-13-trans-eicosatetraenoate + H+
|
1.1.1.232
15-hydroxyicosatetraenoate dehydrogenase
|
–
|
| |
BRENDA:
BR29270
KEGG:
R04518
MetaCyc:
1.1.1.232-RXN
|
|
|
|
leukotriene_A4 + H2O <=> leukotriene_B4
|
3.3.2.6
leukotriene-A4 hydrolase
|
–
|
| |
BRENDA:
BR48209
KEGG:
R03057
MetaCyc:
LEUKOTRIENE-A4-HYDROLASE-RXN
SABIO-RK:
2902
|
|
|
|
prostaglandin_H2 <=> prostaglandin_I2
|
5.3.99.4
prostaglandin-I synthase
|
–
|
| |
BRENDA:
BR6442
KEGG:
R02267
MetaCyc:
PROSTAGLANDIN-I-SYNTHASE-RXN
SABIO-RK:
2234
|
|
|
|
Delta-12-Prostaglandin_J2 <=> 15-deoxy-DELTA12,14-prostaglandin_J2 + H2O
|
not assigned
|
–
|
| |
KEGG:
R07067
|
|
|
|
arachidonic_acid + O2 <=> (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate
|
1.13.11.40
arachidonate 8-lipoxygenase
|
–
|
| |
BRENDA:
BR40471
KEGG:
R01594
|
|
|
|
arachidonic_acid + O2 <=> prostaglandin_G2
|
1.14.99.1
prostaglandin-endoperoxide synthase
|
–
|
| |
BRENDA:
BS387885
KEGG:
R01590
MetaCyc:
RXN-16678
SABIO-RK:
1740
|
|
|
|
11H-14,15-EETA + H2O <=> 11,14,15-THETA
|
1.14.14.1
unspecific monooxygenase
|
–
|
| |
KEGG:
R07045
|
|
|
|
NAD+ + (15S)-hydroxyeicosatetraenoic_acid <=> NADH + 15-Oxo-5,8,11-cis-13-trans-eicosatetraenoate + H+
|
1.1.1.232
15-hydroxyicosatetraenoate dehydrogenase
|
–
|
| |
BRENDA:
BR29270-a
KEGG:
R04517
MetaCyc:
1.1.1.232-RXN_WOP
|
|
|
|
15H-11,12-EETA + H2O <=> 11,12,15-THETA
|
1.14.14.1
unspecific monooxygenase
|
–
|
| |
KEGG:
R07044
|
|
|
|
arachidonic_acid + O2 + NADPH + H+ <=> (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic_acid + NADP+ + H2O
|
1.14.13
1.14.14
1.14.14.1
unspecific monooxygenase
|
–
–
–
|
| |
KEGG:
R07048
|
|
|
|
arachidonic_acid + O2 <=> (5Z,8Z,10E,12R,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoic_acid
|
1.13.11
1.13.11.31
arachidonate 12-lipoxygenase
|
–
–
|
| |
BRENDA:
BS376303
KEGG:
R07038
|
|
|
|
arachidonic_acid + O2 + NADPH + H+ <=> (5Z,8Z,14Z)-11,12-epoxyeicosatrienoic_acid + NADP+ + H2O
|
1.14.13
1.14.14
1.14.14.1
unspecific monooxygenase
|
–
–
–
|
| |
KEGG:
R07050
|
|
|
|
leukotriene_C4 <=> leukotriene_A4 + glutathione
|
4.4.1.20
leukotriene-C4 synthase
|
–
|
| |
BRENDA:
BR48007
KEGG:
R03059
MetaCyc:
LEUKOTRIENE-C4-SYNTHASE-RXN
SABIO-RK:
8569
|
|
|
|
(6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate <=> leukotriene_A4 + H2O
|
1.13.11.34
arachidonate 5-lipoxygenase
|
–
|
| |
BRENDA:
BR49526
KEGG:
R03058
MetaCyc:
RXN-8647
|
|
|
|
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate <=> hepoxilin_A3
|
5.4.4
5.4.4.7
hydroperoxy icosatetraenoate isomerase
|
–
–
|
| |
KEGG:
R07039
MetaCyc:
RXN-14948
|
|
|
|
O2 + arachidonic_acid <=> (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate
|
1.13.11.34
arachidonate 5-lipoxygenase
|
–
|
| |
BRENDA:
BR49525
KEGG:
R01595
MetaCyc:
ARACHIDONATE-5-LIPOXYGENASE-RXN
SABIO-RK:
1744
|
|
|
|
arachidonic_acid + O2 <=> (5Z,8Z,11R,12E,14Z)-11-hydroperoxyicosa-5,8,12,14-tetraenoic_acid
|
1.13.11
|
–
|
| |
KEGG:
R07047
|
|
|
|
prostaglandin_F2alpha + NADP+ <=> prostaglandin_H2 + NADPH + H+
|
1.1.1
1.1.1.188
prostaglandin-F synthase
1.1.1.189
prostaglandin-E2 9-reductase
1.6.99.1
NADPH dehydrogenase
|
–
–
–
–
|
| |
BRENDA:
BS257134
KEGG:
R02264
MetaCyc:
RXN-21136
SABIO-RK:
7732
|
|
|
|
prostaglandin_F2alpha + NADP+ <=> NADPH + prostaglandin_E2 + H+
|
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.189
prostaglandin-E2 9-reductase
|
–
–
|
| |
BRENDA:
BR36706
KEGG:
R02581
MetaCyc:
PROSTAGLANDIN-E2-9-REDUCTASE-RXN
SABIO-RK:
2488
|
|
|
|
thromboxane_A2 + H2O <=> Thromboxane_B2
|
not assigned
|
–
|
| |
KEGG:
R03878
|
|
|
|
arachidonic_acid + O2 + NADPH + H+ <=> (8Z,11Z,14Z)-5,6-epoxyeicosatrienoic_acid + NADP+ + H2O
|
1.14.13
1.14.14.1
unspecific monooxygenase
|
–
–
|
| |
KEGG:
R07052
|
|
|
|
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic_acid + H2O <=> cis-11,12-dihydroxyeicosatrienoic_acid
|
3.3.2.10
soluble epoxide hydrolase
3.3.2.9
microsomal epoxide hydrolase
|
–
–
|
| |
BRENDA:
BS403051
KEGG:
R07109
|
|
|
|
Prostaglandin_D2 + NADPH + H+ <=> 9alpha,11beta-prostaglandin_F2 + NADP+
|
1.1.1.188
prostaglandin-F synthase
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.62
17beta-estradiol 17-dehydrogenase
1.3.1.20
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
|
–
–
–
–
|
| |
BRENDA:
BS371126
KEGG:
R02799
SABIO-RK:
7733
|
|
|
|
prostaglandin_I2 + H2O <=> 6-keto-prostaglandin_F1alpha
|
not assigned
|
–
|
| |
KEGG:
R03521
|
|
|
|
arachidonic_acid + O2 <=> (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
|
1.13.11.31
arachidonate 12-lipoxygenase
|
–
|
| |
BRENDA:
BR37067
KEGG:
R01596
MetaCyc:
ARACHIDONATE-12-LIPOXYGENASE-RXN
SABIO-RK:
1745
|
|
|
|
leukotriene_C4 + H2O <=> leukotriene_D4 + L-glutamate
|
3.4.19.14
leukotriene-C4 hydrolase
|
–
|
| |
BRENDA:
BR49989
KEGG:
R09875
MetaCyc:
RXN-12825
|
|
|
|
prostaglandin_H2 <=> thromboxane_A2
|
5.3.99.5
thromboxane-A synthase
|
–
|
| |
BRENDA:
BR12
KEGG:
R02268
MetaCyc:
THROMBOXANE-A-SYNTHASE-RXN
|
|
|
|
arachidonic_acid + O2 <=> 9(S)-HPETE
|
1.13.11
|
–
|
| |
KEGG:
R07049
|
|
|
|
prostaglandin_J2 <=> Delta-12-Prostaglandin_J2
|
not assigned
|
–
|
| |
KEGG:
R05058
|
|
|
|
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic_acid + H2O <=> (8Z,11Z,14Z)-5,6-dihydroxyeicosa-8,11,14-trienoic_acid
|
3.3.2.10
soluble epoxide hydrolase
3.3.2.9
microsomal epoxide hydrolase
|
–
–
|
| |
BRENDA:
BS403082
KEGG:
R07111
|
|
|
|
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate <=> hepoxilin_B3
|
5.4.4
|
–
|
| |
KEGG:
R07040
|
|
|
|
arachidonic_acid + reduced_flavodoxin + O2 <=> 20-hydroxyeicosatetraenoic_acid + flavin + H2O
|
1.14.14.78
phylloquinone omega-hydroxylase
1.14.14.79
docosahexaenoic acid omega-hydroxylase
1.14.14.80
long-chain fatty acid omega-monooxygenase
1.14.14.94
leukotriene-B4 20-monooxygenase
|
–
–
–
–
|
| |
BRENDA:
BS375050
KEGG:
R07041
|
|
|
|
5,6-Epoxytetraene + H2O <=> lipoxin_B4
|
3.3.2
|
–
|
| |
KEGG:
R07032
|
|
|
|
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic_acid + H2O <=> cis-14,15-dihydroxyeicosatrienoic_acid
|
3.3.2.10
soluble epoxide hydrolase
3.3.2.9
microsomal epoxide hydrolase
|
–
–
|
| |
BRENDA:
BS403050
KEGG:
R07108
|
|
|
|
hepoxilin_B3 + H2O <=> trioxilin_b3
|
3.3.2
3.3.2.7
hepoxilin-epoxide hydrolase
|
–
–
|
| |
BRENDA:
BS448671
KEGG:
R07037
|
|
|
|
O2 + arachidonic_acid <=> (5Z,9E,11Z,14Z)-(8S)-8-hydroperoxyeicosa-5,9,11,14-tetraenoate
|
1.13.11
1.13.11.40
arachidonate 8-lipoxygenase
|
–
–
|
| |
BRENDA:
BS375051
KEGG:
R07053
MetaCyc:
ARACHIDONATE-8-LIPOXYGENASE-RXN
|
|
|
|
6-keto-prostaglandin_F1alpha + acceptor <=> 6-ketoprostaglandin_E1 + reduced_acceptor
|
not assigned
|
–
|
| |
KEGG:
R05059
|
|
|
|
Prostaglandin_B2 <=> Prostaglandin_C2
|
not assigned
|
–
|
| |
KEGG:
R05057
|
|
|
|
15-hydroperoxyeicosatetraenoic_acid <=> 15H-11,12-EETA
|
1.14.14.1
unspecific monooxygenase
|
–
|
| |
KEGG:
R07042
|
|
|
|
prostaglandin_F2alpha + NAD+ <=> 15-ketoprostaglandin_F2alpha + NADH + H+
|
1.1.1.141
15-hydroxyprostaglandin dehydrogenase (NAD+)
1.1.1.196
15-hydroxyprostaglandin-D dehydrogenase (NADP+)
1.1.1.231
15-hydroxyprostaglandin-I dehydrogenase (NADP+)
|
–
–
–
|
| |
BRENDA:
BS187205-a
KEGG:
R02683
MetaCyc:
RXN-21138
|
|
|
|
prostaglandin_E2 <=> Prostaglandin_A2 + H2O
|
not assigned
|
–
|
| |
KEGG:
R02583
|
|
|
|
Prostaglandin_D2 <=> prostaglandin_J2 + H2O
|
not assigned
|
–
|
| |
KEGG:
R02801
|
|
|
|
leukotriene_E4 + L-glutamate <=> Leukotriene_F4 + H2O
|
2.3.2
|
–
|
| |
KEGG:
R05207
|
|
|
|
2 glutathione + (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate <=> GSSG + 5-hydroxyeicosatetraenoic_acid + H2O
|
1.11.1.9
glutathione peroxidase
|
–
|
| |
KEGG:
R07034
SABIO-RK:
7538
|
|
|
|
15-hydroperoxyeicosatetraenoic_acid <=> 11H-14,15-EETA
|
1.14.14.1
unspecific monooxygenase
|
–
|
| |
KEGG:
R07043
|
|
|
|
prostaglandin_H2 <=> Prostaglandin_D2
|
5.3.99.2
prostaglandin-D synthase
5.3.99.3
prostaglandin-E synthase
5.3.99.4
prostaglandin-I synthase
|
–
–
–
|
| |
BRENDA:
BR9
KEGG:
R02266
MetaCyc:
PROSTAGLANDIN-D-SYNTHASE-RXN
SABIO-RK:
2233
|
|
|
|
Thromboxane_B2 + acceptor <=> 11-Dehydro-thromboxane_B2 + reduced_acceptor
|
not assigned
|
–
|
| |
KEGG:
R05060
|
|
|
|
2 glutathione + 15-hydroperoxyeicosatetraenoic_acid <=> GSSG + (15S)-hydroxyeicosatetraenoic_acid + H2O
|
1.11.1.9
glutathione peroxidase
|
–
|
| |
KEGG:
R07035
|
|
|
|
leukotriene_B4 + reduced_flavodoxin + O2 <=> 20-hydroxy-leukotriene_B4 + flavin + H2O
|
1.14.14.78
phylloquinone omega-hydroxylase
1.14.14.94
leukotriene-B4 20-monooxygenase
|
–
–
|
| |
BRENDA:
BR36761
KEGG:
R03866
|
|
